Description      An odorless, white to off-white crystalline power

Conforms

Identification:    

         1.    Exhibit maxima at 267nm, 277nm, and 288nm

Conforms

2.      The retention time of the peaks for the cis-and

 trans-stereoisomers in the chromatogram of the assay preparation

 corresponds to those of the standard preparation as obtained in

the assay respectively

Conforms

3.   The infrared absorption spectrum is concordant with the

Spectrum of sirolimus reference standard.

Conforms

Impurity:             NMT2.0%

0.2%

Ratio of isomer:      Trans-stereoisomer NLT95.0%

96.9%

Water:               NMT0.5%

0.1%

Heavy metals:         NMT20ppm

Conforms

Assay:             98.0~102.0%(Calculated cis-and trans-stereisomers of

                Sirolimus on the anhydrous basis)

99.5%